A user equipment (UE), such as a full-duplex UE, may receive a downlink transmission from a first transmit-receive point (TRP) in a full-duplex multi-TRP configuration. The UE may perform an uplink transmission to a second TRP in the full-duplex multi-TRP configuration based at least in part on a timing advance adjustment associated with the uplink transmission. The UE may apply the timing advance adjustment based at least in part on an indication received from a base station. The indication may be to set a timing advance offset to a value that satisfies a threshold value based at least in part on the downlink transmission and the uplink transmission being associated with two different TRPs. The downlink transmission and the uplink transmission may not be separated by a guard symbol when the downlink transmission and the uplink transmission are associated with the two different TRPs, which may improve a resource utilization.