The present invention discloses an “inferior-eliminating and superior-selecting” breeding method for synergistically improving wheat yield and quality. A method for breeding target wheat varieties with improved yield and quality is provided herein, which combines the advantages of pedigree method and hybrid method, and provides a method for selection of all generations using molecular marker in combination with phenotype identification, and for selection of each generation according to different standards. Different from the derivative system method, the method reserves the traceability of line history and genetic relationship and the characteristics of simple operation and abundant genetic diversity of the hybrid method. The parents have clear backgrounds before combination and the selection process is simple and easy to operate, with clear goal, especially for those with no breeding experiences, it is easy to master and provides technical support for the rapid breeding of new varieties of high-quality and high-yield wheat.