Invention Grant
- Patent Title: Human liver chimeric mouse with deficient P450 oxidoreductase
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Application No.: US16309871Application Date: 2017-06-27
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Publication No.: US11716974B2Publication Date: 2023-08-08
- Inventor: Karl-Dimiter Bissig , Maria de las Mercedes Barzi Dieguez , Peter Francis Pankowicz
- Applicant: Baylor College of Medicine
- Applicant Address: US TX Houston
- Assignee: Baylor College of Medicine
- Current Assignee: Baylor College of Medicine
- Current Assignee Address: US TX Houston
- Agency: Cooley LLP
- Agent Matthew Pavao
- International Application: PCT/US2017/039474 2017.06.27
- International Announcement: WO2018/005471A 2018.01.04
- Date entered country: 2018-12-13
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A61K49/00
Abstract:
The present disclosure provides a chimeric non-human animal comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to screening and identifying metabolites for any type of drugs, typically small molecule drugs, which might affect human liver functions and any other bodily function.
Public/Granted literature
- US20190166810A1 HUMAN LIVER CHIMERIC NON-HUMAN ANIMAL WITH DEFICIENT P450 OXIDOREDUCTASE AND METHODS OF USING SAME Public/Granted day:2019-06-06
Information query
