Invention Grant
- Patent Title: Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy
-
Application No.: US16739407Application Date: 2020-01-10
-
Publication No.: US11717548B2Publication Date: 2023-08-08
- Inventor: Darrell J. Irvine , Karl Dane Wittrup , Ron Weiss , Yingzhong Li , Noor Momin , Yizhou Dong
- Applicant: Massachusetts Institute of Technology , Ohio State Innovation Foundation
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology,Ohio State Innovation Foundation
- Current Assignee: Massachusetts Institute of Technology,Ohio State Innovation Foundation
- Current Assignee Address: US MA Cambridge; US OH Columbus
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K35/768
- IPC: A61K35/768 ; A61P35/00 ; A61K9/00 ; C07K14/54 ; C12N7/00
Abstract:
The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
Public/Granted literature
- US20200281994A1 SYNTHETIC ONCOLYTIC LNP-REPLICON RNA AND USES FOR CANCER IMMUNOTHERAPY Public/Granted day:2020-09-10
Information query
IPC分类:
