Invention Grant
- Patent Title: Pharmaceutical compositions having a selected release duration
-
Application No.: US16954984Application Date: 2017-12-18
-
Publication No.: US11717555B2Publication Date: 2023-08-08
- Inventor: Yuhua Li , Andrew Guarino
- Applicant: Foresee Pharmaceuticals Co., Ltd.
- Applicant Address: TW Taipei
- Assignee: Foresee Pharmaceuticals Co., Ltd.
- Current Assignee: Foresee Pharmaceuticals Co., Ltd.
- Current Assignee Address: TW Taipei
- Agency: MagStone Law, LLP
- Agent Enshan Hong
- International Application: PCT/US2017/066968 2017.12.18
- International Announcement: WO2019/125358A 2019.06.27
- Date entered country: 2020-06-17
- Main IPC: A61K38/09
- IPC: A61K38/09 ; A61K47/34 ; A61K9/00 ; A61K47/22

Abstract:
The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a strong acid salt of a LHRH agonist or antagonist; b) a biodegradable polymer of poly(lactide-co-glycolide), wherein the ratio of lactide:glycolide of the copolymer is from 50:50 to about 100:0; and c) N-methyl-2-pyrrolidone (NMP), wherein the composition does not contain excess strong acid in addition to the strong acid used to form the salt of the LHRH agonist or antagonist. The composition, when injected, can provide a controlled release of leuprolide for a period of up to 6 months.
Information query
IPC分类: