Invention Grant
- Patent Title: Recombinant BCG overexpressing
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Application No.: US16500934Application Date: 2017-04-07
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Publication No.: US11717565B2Publication Date: 2023-08-08
- Inventor: Jun Liu
- Applicant: Chengdu Anyong Dingye Biotechnology Co., Ltd.
- Applicant Address: CN Chengdu
- Assignee: CHENGDU ANYONG DINGYE BIOTECHNOLOGY CO., LTD.,LTD.
- Current Assignee: CHENGDU ANYONG DINGYE BIOTECHNOLOGY CO., LTD.,LTD.
- Current Assignee Address: CN Chengdu; CN Chengdu
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/CN2017/079665 2017.04.07
- International Announcement: WO2018/184188A 2018.10.11
- Date entered country: 2019-10-04
- Main IPC: A61K39/04
- IPC: A61K39/04 ; A61P31/06 ; C12N1/20 ; C12R1/32
Abstract:
Provided are a live recombinant Mycobacterium bovis-BCG strain and a tuberculosis (TB) vaccine or immunogenic composition comprising a nucleic acid capable of overexpression, the nucleic acid encoding PhoP and PhoR proteins. A method for treatment or prophylaxis of a mammal against challenge by Mycobacterium tuberculosis or Mycobacterium bovis using the strain is also provided.
Public/Granted literature
- US20200254080A1 RECOMBINANT BCG OVEREXPRESSSING phoP-phoR Public/Granted day:2020-08-13
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