Disclosed are a scratch-proof TPU (thermoplastic polyurethane) cutting board having increased wear resistance and no toxicity and a method of manufacturing the same, the method according to a preferred embodiment including (1) weighing 72 wt % of TPU, 25 wt % of magnesium sulfate, and 3 wt % of a dispersant, (2) placing the materials weighed in step (1) in a mixing tank and performing mixing with stirring for 40 min, (3) placing the mixed materials in a dryer and performing drying at 80° C. for 3 hr, and (4) placing the dried materials in an injection-molding machine and performing injection molding, whereby the molecular cohesion of TPU and magnesium sulfate is enhanced, whereby the final TPU cutting board has greatly increased wear resistance and friction resistance and is non-toxic, and surface scratches do not occur due to a cutting process when using the cutting board, thereby preventing discoloration of the surface of the cutting board.