A printing machine comprises a printing module (28) having a flexographic printing mode and a gravure printing mode, wherein the printing module comprises at least two printing cylinders (34, 36) defining the printing mode of the printing module, and a printing tool handling unit being configured for withdrawing and inserting the at least two printing cylinders (34, 36) from and into the printing module, respectively. The printing tool handling unit comprises a coupling interface and the at least two printing cylinders each comprise a complementary coupling interface such that the printing tool handling unit can at least temporarily be coupled to one or more of the at least two printing cylinders (34, 36) via the respective coupling interfaces.