Some embodiments of the methods and compositions provided herein relate to the detection of biomarkers for Kawasaki disease (KD), the diagnosis of KD in a subject, and/or the amelioration or treatment of KD in a subject. In some embodiments, a biomarker can include a long intergenic non-coding RNA (lincRNA). In some embodiments, the biomarker can be present in an exosome-enriched serum sample from a subject.