• Patent Title: EML4-ALK gene mutation analysis method
  • Application No.: US16631324
    Application Date: 2018-07-17
  • Publication No.: US11718882B2
    Publication Date: 2023-08-08
  • Inventor: Byung Hee Jeon
  • Applicant: CYTOGEN, INC.
  • Applicant Address: KR Seoul
  • Assignee: CYTOGEN, INC.
  • Current Assignee: CYTOGEN, INC.
  • Current Assignee Address: KR Seoul
  • Agency: Sughrue Mion, PLLC
  • Priority: KR 20170099591 2017.08.07
  • International Application: PCT/KR2018/008046 2018.07.17
  • International Announcement: WO2019/031722A 2019.02.14
  • Date entered country: 2020-01-15
  • Main IPC: C12Q1/6886
  • IPC: C12Q1/6886 C12Q1/6806 C12Q1/6827
EML4-ALK gene mutation analysis method
Abstract:
qRT-PCR primers capable of detecting EML4-ALK gene variant based on circulating tumor cells at a more sensitive detection limit than a conventional method. Also disclosed is a lung cancer patient screening method which is capable of detecting EML4-ALK gene variant using circulating tumor cells even in a lung cancer patient on whom ALK-FISH testing has been difficult to perform, due to difficulty in collecting a solid lung cancer tissue sample, and is able to determine whether an anticancer drug targeting the EML4-ALK gene variant may be applied to the lung cancer patient.
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