A multi-axial wave energy conversion device includes a carrier, a main body coupled to the carrier, a wave energy conversion assembly, a rotating mechanism, a lifting mechanism and a control unit electrically connected to the rotating mechanism and the lifting mechanism. The wave energy conversion assembly is coupled to the main body and includes an arm. The rotating mechanism is coupled between the carrier and the main body. The lifting mechanism is coupled between the arm and the main body. The control unit is for controlling the rotating mechanism to drive the main body to rotate relative to the carrier around a vertical axis for adjusting an orientation of the arm relative to the carrier, and further for controlling the lifting mechanism to drive the arm to rotate relative to the main body around a horizontal axis for adjusting an included angle between the arm and the main body.