A driving system for driving piezoelectric pump includes one or more mechanical devices and a driving circuit system electrically connected to the at least one mechanical device. The driving circuit system includes a pump-driving unit, a linear voltage-stabilizing unit, a microcontroller unit, a current-sensing unit, and a connection unit. The microcontroller unit generates a first signal, a second signal, and a third signal, and the pump-driving unit receives these signals to drive the mechanical device. The current-sensing unit receives a fourth signal transmitted by the pump-driving unit to obtain an actuation current value of the mechanical device. The linear voltage-stabilizing unit, the current-sensing unit, and the microcontroller unit are coupled to each other through a fifth signal and a sixth signal. The connection unit and the microcontroller unit are coupled to each other through a reset signal, a seventh signal, and an eighth signal provided by the microcontroller unit.