An information handling system bus port above a subject information handling system bus device may host an information handling system bus out of band message access control list of information handling system bus target device identifiers of other information handling system bus connected devices that the subject device is permitted to communicate with. The port may compare an information handling system bus target device identification field in out of band messages from the subject device to the list and route only out of band messages from the subject device in which the target device identification in the target device identification field is on the access control list through the information handling system bus. The port may discard (and generate error notifications, statuses, etc.) for out of band messages in which the target device identification in the target device identification field is not on the access control list.