A method and system (and/or a total simulation) have at least first and second sub-systems. An interconnection network is determined, which couples and determines the first and the second sub-systems at a coupling. First sub-system information of the first sub-system and second sub-system information of the second sub-system are determined. An execution sequence is selected, by which it is determined, in which sequence relative to each other a first and a second parameter outputs are determined. Furthermore, extrapolation methods are determined, by which first and second parameter inputs are determinable during a macro step size (e.g. between the coupling times). The macro step size prescribes-coupling times, at which an exchange of corresponding first and second input parameters and of the first and the second output parameters between the sub-systems is performed. The coupling of the sub-systems is configured based on the interconnection network, the first sub-system information and the second sub-system information, the execution sequence, the extrapolation methods, and the macro step size, and the co-simulation is performed.