Systems and methods for efficient implementation of a convolutional layer of a convolutional neural network are disclosed. In one aspect, weight values of kernels in a kernel stack of a convolutional layer can be reordered into a tile layout with tiles of runnels. Pixel values of input activation maps of the convolutional layer can be reordered into an interleaved layout comprising a plurality of clusters of input activation map pixels. The output activation maps can be determined using the clusters of the input activation map pixels and kernels tile by tile.