To provide a high-voltage fuel cell. The fuel cell is a fuel cell comprising an anode-side gas diffusion layer, an anode catalyst layer, an electrolyte membrane, a cathode catalyst layer and a cathode-side gas diffusion layer in this order, wherein a gas diffusion resistance ratio of the anode-side gas diffusion layer to the cathode-side gas diffusion layer is more than 1.50 and less than 2.79; wherein a gas diffusion resistance value of the cathode-side gas diffusion layer is 84 S/m or less at a relative humidity of 165%; and wherein a gas diffusion resistance value of the anode-side gas diffusion layer is less than 234 S/m at a relative humidity of 165%.