A denial-of-service detection system includes a denial-of-service detection subsystem coupled to a plurality of storage systems via a network. The denial-of-service detection subsystem receives current first storage system data for each of a plurality of different storage system operating metrics from a first storage system included in the plurality of storage systems. Based on a historical storage system data for each of the plurality of different storage system operating metrics that was previously received from the plurality of storage devices, the denial-of-service subsystem detects an operating anomaly in the current first storage system data for at least one of the plurality of different storage system operating metrics, identifies a time-series similarity in a subset of respective time-series of the current first storage system data for each of the plurality of different storage system operating metrics for which the operating anomaly was detected and, in response, performs a denial-of-service remediation action.