Invention Grant
- Patent Title: Application of trans-1,3-dilinolein in the preparation of medicaments for treating gastric cancer, stomachic tonic, health products and foods
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Application No.: US17450845Application Date: 2021-10-14
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Publication No.: US11744818B2Publication Date: 2023-09-05
- Inventor: Jianye Dai , Zheng Jin , Ruyun Ma , Yanning Zhu
- Applicant: Lanzhou University
- Applicant Address: CN Lanzhou
- Assignee: Lanzhou University
- Current Assignee: Lanzhou University
- Current Assignee Address: CN Lanzhou
- Agency: AVEK IP, LLC
- Priority: CN 2110026727.7 2021.01.09
- Main IPC: A61K31/231
- IPC: A61K31/231 ; A61P35/00

Abstract:
Some embodiments of the disclosure provide new uses of trans-1,3-dilinolein as medicaments and food. In an embodiment, an application of trans-1,3-dilinolein in the preparation of stomachic tonic and an application thereof include the preparation of medicaments for treating gastric cancer. Cell experiments show that trans-1,3-dilinolein promotes the proliferation of human gastric mucosal epithelial cell line GES-1 under normal oxygen and hypoxic conditions and it has concentration-dependent killing effect on human gastric cancer cell line HGC-27 and killing effect on hypoxic gastric cancer cells. At a concentration of 300 μm and more, trans-1,3-dilinolein kills gastric cancer cells significantly and the killing effect becomes more significant under hypoxic conditions.
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