Invention Grant
- Patent Title: Compositions and methods for treating defects in avascular cartilaginous tissue by directly administering one or more metabolites of simvastatin
-
Application No.: US16613510Application Date: 2018-05-15
-
Publication No.: US11744821B2Publication Date: 2023-09-05
- Inventor: Chia-Ying James Lin
- Applicant: University of Cincinnati
- Applicant Address: US OH Cincinnati
- Assignee: University of Cincinnati
- Current Assignee: University of Cincinnati
- Current Assignee Address: US OH Cincinnati
- Agency: DINSMORE & SHOHL LLP
- International Application: PCT/US2018/032635 2018.05.15
- International Announcement: WO2018/213221A 2018.11.22
- Date entered country: 2019-11-14
- Main IPC: A61K31/366
- IPC: A61K31/366 ; A61K9/00 ; A61P19/04
Abstract:
Controlled release hydrogel formulations of one or more simvastatin metabolites 3′-hydroxy simvastatin (hSV), 6′-exomethylene simvastatin (eSV), 3′,5′-dihydrodiol simvastatin, 3′,5′-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.
Public/Granted literature
Information query
