Invention Grant
- Patent Title: Nanodiamonds as artificial proteins for regulation of a cell signalling system
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Application No.: US16981578Application Date: 2019-03-26
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Publication No.: US11744855B2Publication Date: 2023-09-05
- Inventor: Petr Cigler , Lukas Balek , Jan Havlik , Pavel Krejci , Lukas Trantirek , Silvie Trantirkova
- Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , MASARYKOVA UNIVERZITA , FAKULTNI NEMOCNICE U SV. ANNY V BRNE
- Applicant Address: CZ Prague
- Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I,MASARYKOVA UNIVERZITA,FAKULTNI NEMOCNICE U SV, ANNY V BRNE
- Current Assignee: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I,MASARYKOVA UNIVERZITA,FAKULTNI NEMOCNICE U SV, ANNY V BRNE
- Current Assignee Address: CZ Prague; CZ Brno; CZ Brno
- Agency: Notaro, Michalos & Zaccaria P.C.
- Priority: EP 165299 2018.03.30
- International Application: PCT/EP2019/057649 2019.03.26
- International Announcement: WO2019/185667A 2019.10.03
- Date entered country: 2020-09-16
- Main IPC: A61K33/44
- IPC: A61K33/44 ; A61K9/14 ; A61K45/06 ; C07K14/50
Abstract:
Nanodiamonds having a positive ζ-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ζ-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.
Public/Granted literature
- US20210015856A1 NANODIAMONDS AS ARTIFICIAL PROTEINS FOR REGULATION OF A CELL SIGNALLING SYSTEM Public/Granted day:2021-01-21
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