Invention Grant
- Patent Title: Cross-linkable microgel composite matrix bath for embedded bioprinting of perfusable tissue constructs
-
Application No.: US17859593Application Date: 2022-07-07
-
Publication No.: US11745412B2Publication Date: 2023-09-05
- Inventor: Ashley M. Compaan , Yong Huang , Kaidong Song , Wenxuan Chai
- Applicant: University of Florida Research Foundation, Incorporated
- Applicant Address: US FL Gainesville
- Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee Address: US FL Gainesville
- Agency: ALSTON & BIRD LLP
- The original application number of the division: US16703691 2019.12.04
- Main IPC: B29C64/118
- IPC: B29C64/118 ; B33Y70/10 ; B29C64/40 ; A61L27/44 ; A61L27/56 ; A61L27/52 ; B29K105/00 ; B29K105/16 ; B29L31/40

Abstract:
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.
Public/Granted literature
- US20220410470A1 CROSS-LINKABLE MICROGEL COMPOSITE MATRIX BATH FOR EMBEDDED BIOPRINTING OF PERFUSABLE TISSUE CONSTRUCTS Public/Granted day:2022-12-29
Information query
IPC分类: