This disclosure relates to a system and method for isolating an interior of a motor vehicle from poor outdoor air quality. More particularly, this disclosure relates to a system and method configured to identify conditions associated with poor outdoor air quality and to respond to those conditions by isolating the interior of the motor vehicle from the outdoor environment. An example system includes a selector configured to permit a user to select a drive mode of the motor vehicle, a location system configured to detect a location of the motor vehicle, and a controller configured to issue one or more commands to isolate an interior of the motor vehicle from an environment outside the motor vehicle based on either a selected drive mode or a detected location.