Invention Grant
- Patent Title: Process for the production of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methyl-morpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine
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Application No.: US17032232Application Date: 2020-09-25
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Publication No.: US11746107B2Publication Date: 2023-09-05
- Inventor: Grzegorz Witkowski , Marta Magdycz , Magdalena Tyszkiewicz , Marcin Zakrzewski , Stanislaw Pikul
- Applicant: Molecure S.A.
- Applicant Address: PL Warsaw
- Assignee: Molecure S.A.
- Current Assignee: Molecure S.A.
- Current Assignee Address: PL Warsaw
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon; Laura A. Wzorek
- Priority: PL 1269 2019.09.25
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D211/74 ; C07D413/04
Abstract:
The present invention relates to a process for the synthesis of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine in two hydrated crystalline forms and in one anhydrous crystalline form. The present invention further relates to methyl (Z)-4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)-N-cyanopiperidine-1-carbimidothioate which is an intermediate in this process.
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