Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of



(I) reacting a compound of formula (III)












with an azide of formula (IV)














to prepare a compound of formula (V)












(II) reacting a compound of formula (V) with a thiol-containing molecule of formula (VI)












resulting in a compound of formula (VII)