Invention Grant
- Patent Title: Thermostable FGF2 polypeptide, use thereof
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Application No.: US15778743Application Date: 2016-10-03
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Publication No.: US11746135B2Publication Date: 2023-09-05
- Inventor: Petr Dvorak , Pavel Krejci , Lukas Balek , Livia Eiselleova , Zaneta Konecna , Pavel Dvorak , David Bednar , Jan Brezovsky , Eva Sebestova , Radka Chaloupkova , Veronika Stepankova , Pavel Vanacek , Zbynek Prokop , Jiri Damborsky , Michaela Bosakova
- Applicant: Masarykova Univerzita , Enantis s.r.o.
- Applicant Address: CZ Brno
- Assignee: Masarykova Univerzita,Enantis s.r.o.
- Current Assignee: Masarykova Univerzita,Enantis s.r.o.
- Current Assignee Address: CZ Brno; CZ Brno
- Agency: Wood Herron & Evans LLP
- Priority: EP 196802 2015.11.27
- International Application: PCT/EP2016/073567 2016.10.03
- International Announcement: WO2017/089016A 2017.06.01
- Date entered country: 2018-05-24
- Main IPC: C07K14/50
- IPC: C07K14/50 ; C12N5/00
Abstract:
The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
Public/Granted literature
- US20200270320A1 Thermostable FGF2 Polypeptide, Use Thereof Public/Granted day:2020-08-27
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