Invention Grant
- Patent Title: Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
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Application No.: US16959390Application Date: 2019-01-05
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Publication No.: US11746330B2Publication Date: 2023-09-05
- Inventor: Andrew F. Stewart , Courtney Ackeifi , Peng Wang , Bob Devita
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Troutman Pepper Hamilton Sanders LLP (Rochester)
- International Application: PCT/US2019/012442 2019.01.05
- International Announcement: WO2019/136320A 2019.07.11
- Date entered country: 2020-06-30
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/071 ; A61P5/48 ; A61P3/10 ; A61K31/437 ; A61K38/22
Abstract:
Disclosed herein are methods of increasing cell proliferation in a population of pancreatic beta cells. Also disclosed are methods of treating a subject for a condition associated with insufficient insulin secretion. Also disclosed is a composition comprising a DYRK1 A inhibitor and a GLP1R agonist. The disclosure further describes a method of regenerating pancreatic beta cells in a transplant patient.
Public/Granted literature
- US11788064B2 Method of increasing proliferation of pancreatic beta cells, treatment method, and composition Public/Granted day:2023-10-17
Information query
