Methods to improve fluid flow of a multi-phase mixture, methods to separate fluids of a multi-phase mixture, and downhole multi-phase fluid mixture systems are disclosed. A method to improve fluid flow of a multi-phase mixture includes positioning a first acoustic device and a second acoustic device around a conveyance that provides a fluid flow path for a first fluid in a first phase and a second fluid in a second phase to simultaneously flow through the conveyance. The method also includes determining a flow rate and a fluid condition of the fluid mixture. The method further includes generating a standing acoustic wave through the conveyance based on the flow rate and the fluid condition to break down the first fluid into droplets having volume within a threshold volume.