A building system of a building includes an in-zone plume control system located within a zone of the building, the in-zone plume control system including one or more return air inlets comprising openings to receive one or more air plumes generated by one or more users. The in-zone plume control system includes one or more exhaust outlets configured to exhaust the one or more air plumes, a filter, and a fan configured to draw the one or more air plumes in through the one or more return air inlets, through the filter, and out through the one or more exhaust outlets back into the zone, wherein the filter is configured to filter the one or more air plumes to remove particles from the one or more air plumes before returning the one or more air plumes to the zone.