The present disclosure is directed to techniques for actuation of a magnetic resonance device for generating a high frequency pulse for specific saturation of nuclear spins in an examination region of an examination object. The techniques may include providing a frequency spectrum of the examination region, providing a B0 field map, establishing a first resonance frequency for a first tissue and a second resonance frequency for a second tissue taking account of the frequency spectrum, determining a saturation pulse by establishing a high frequency pulse configured for a spectrally selective excitation of the first tissue and the second tissue taking account of the first resonance frequency, the second resonance frequency and the B0 field map, and outputting the saturation pulse by means of the high frequency antenna unit.