The disclosed threat response system(s) and method(s) provide a mean to secure an area around the clock. The system includes a plurality of microphones strategically located at various locations of the protected area, a plurality of acoustic beacons to provide navigational support one or more autonomous non-flying (ANF) drones, and a central controller. In one example each of the one or more ANF drones are equipped with an acoustic positioning system that uses beacon signals (e.g., mechanical waves) transmitted by the plurality of acoustic beacons to determine its position relative to the plurality of acoustic beacons. Once an acoustic event is detected, it is analyzed to determine whether there is a threat. When the threat is confirmed, the central controller dispatches one or more of the ANF drones to investigate and/or to engage the target.