Systems and methods for event notification support for nested virtual machines. An example method may comprise running, by a host computer system, a Level 0 hypervisor managing a Level 1 virtual machine running a Level 1 hypervisor, wherein the Level 1 hypervisor manages a Level 2 virtual machine. The Level 1 hypervisor may generate a virtual device and an input/output (I/O) translation table comprising an I/O translation table entry associated with the virtual device, and associate the I/O translation table entry with a Level 1 virtual machine context maintained by at least one of the Level 0 hypervisor or Level 1 hypervisor. The method may further responsive to detecting, by the Level 0 hypervisor, an event notification from the Level 2 virtual machine, cause a central processing unit (CPU) to use the I/O translation table to execute access to the Level 1 guest virtual address.