The present disclosure provides a hot-plugging control method, device, and retimer. The hot-plugging control method includes: receiving data from a pluggable device through a second end, sending the data to an RC through a first end; sending a detection signal to the second end to detect the connection status between the pluggable device and the second end; and stopping sending the data to the RC, and sending the first control signal to the RC, when it is detected that the pluggable device is hot-unplugged from the second end, so that the RC handles the abnormal state of the data not being sent according to the first control signal. The hot-plugging control method provided by the present disclosure does not require presence signals to implement hot-plugging of a pluggable device, and thus can avoid the problem that the device cannot implement hot-plugging without presence signals.