A system providing a multi-persona social agent includes a computing platform having a hardware processor, a system memory storing a software code, and multiple neural network (NN) based predictive models accessible by the software code. The hardware processor executes the software code to receive input data corresponding to an interaction with a user, determine a generic expression for use in the interaction, and identify one of the character personas as a persona to be assumed by the multi-persona social agent. The software code also generates, using the generic expression and one of the NN based predictive models corresponding to the persona to be assumed by the multi-persona social agent, a sentiment driven personified response for the interaction with the user based on a vocabulary, phrases, and one or more syntax rules idiosyncratic to the persona to be assumed, and renders the sentiment driven personified response using the multi-persona social agent.