An automated package Pickup and Receiving Station (PRS) (100) with autonomous ground vehicles (AGV) (18) are presented, which may be used to pick up, deliver and securely store packages (28), parcels, mail, prepared food, groceries or other items that may be placed in a tray, which may include an integrated container. A portal (10) facilitates loading of items into, and removal of items from, the PRS (100). Within the PRS (100), items (28) may be transported from source to destination on standardized trays (25), via a two-dimensional gantry (32) and an end of arm tool (22). The gantry (32) may be oriented for movement through a central corridor (21) in the PRS (100), with end of arm tool (22) adapted for pushing trays towards, or pulling trays from, either side of the gantry (32). Items may be stored on a tray (25) in internal shelving (20), or placed directly into an AGV (18), on either side of the PRS (100).