The invention relates to commodity anti-counterfeit verification system based on natural biological information. The system includes an anti-counterfeit information generation module used for generating unique anti-counterfeit information corresponding to a commodity, an anti-counterfeit database used for storing the unique anti-counterfeit information generated by the anti-counterfeit information generation module, and an anti-counterfeit information verification module used for carrying out anti-counterfeit verification on the commodity according to the unique anti-counterfeit information stored in the anti-counterfeit database. The anti-counterfeit information generation module comprises an identity information generator, a natural biological information generation assembly, and an information binder. Compared with the prior art, the system has the advantages of being easy to implement, good in anti-counterfeit performance, capable of reducing costs, and the like.