An equipment locking and de-energization management system (7) is configured to guarantee safety during the locking and de-energization of a power source (6) of an item of equipment (7) during maintenance thereof. The system includes an intelligent lock (1) to be inserted into the power source (6) and perform the locking thereof, a control device (2) configured to manage and sort the locking steps and a central server (15) to assist with the communication between the elements of the locking and de-energization management system. Also described is an equipment locking and de-energization management method (7) which makes use of the locking and de-energization management system, enhancing the safety, efficiency and productivity during locking and de-energization of the power source (6) of an item of equipment (7) undergoing maintenance.