Invention Grant
- Patent Title: Immunoglobulin binding protein, and affinity support using same
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Application No.: US16649879Application Date: 2018-09-25
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Publication No.: US11753449B2Publication Date: 2023-09-12
- Inventor: Jun-ichi Yasuoka , Kiichi Yoshimura
- Applicant: JSR CORPORATION , JSR Life Sciences Corporation , JSR Life Sciences, LLC , JSR Micro N. V.
- Applicant Address: JP CA Minato-ku
- Assignee: JSR CORPORATION,JSR Life Sciences Corporation,JSR Life Sciences, LLC,JSR Micro N.V.
- Current Assignee: JSR CORPORATION,JSR Life Sciences Corporation,JSR Life Sciences, LLC,JSR Micro N.V.
- Current Assignee Address: JP Minato-ku; JP Minato-ku; US CA Sunnyvale; BE Leuven
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP 17184158 2017.09.25
- International Application: PCT/JP2018/035418 2018.09.25
- International Announcement: WO2019/059399A 2019.03.28
- Date entered country: 2020-03-23
- Main IPC: C07K14/195
- IPC: C07K14/195 ; C07K1/22 ; C07K14/00 ; C12P21/02

Abstract:
Provided are a protein L-derived immunoglobulin binding protein having an increased alkali tolerance, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.
Public/Granted literature
- US20210163545A1 IMMUNOGLOBULIN BINDING PROTEIN, AND AFFINITY SUPPORT USING SAME Public/Granted day:2021-06-03
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