An example method may include allocating, on a host computer system, a memory page in a memory of an input/output (I/O) device, mapping the memory page into a memory space of a virtual machine associated with a first virtual processor, creating a first entry in an interrupt mapping table in the memory of the I/O device, where the first entry includes a memory address that is associated with a second virtual processor identifier and further includes an interrupt vector identifier; and creating a second entry in an interrupt injection table of an interrupt injection unit of the host computer system, where the second entry is associated with a memory address that corresponds to a second virtual processor, the second entry includes the interrupt vector identifier, and the second entry is further associated with the second virtual processor identifier.