Various embodiments of the present disclosure relate to transmitter systems, methods, and instructions for signal predistortion. The transmitter system includes an intermodulation distortion (IMD) filter module configured to filter a detected feedback signal (Yin) to generate a targeted filtered signal (Yout), a digital pre-distortion (DPD) coefficient estimation module configured to update signal generation coefficients based on comparing an input signal (Sin) with the targeted filtered signal (Yout), and a distortion compensation processing module configured to generate a pre-distorted signal (Uout) based on the input signal (Sin) using the updated signal generation coefficients.