The present invention relates to the technical field of charging wireless earphones, in particular to a wireless earphone charging case convenient for replacing outer shells. Its outer shell has an upper shell and a lower shell that are capable of being disengaged/engaged from/with each other, wherein a containing space is arranged inside the lower shell, a charging chamber is arranged within the containing space, a screw slot is arranged on bottom of the charging chamber, the bottom of the lower shell is fixed to the screw slot on the bottom of the charging chamber by means of a metal screw.