Invention Grant
- Patent Title: Method of preparing a DON prodrug from L-pyroglutamic acid
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Application No.: US17430285Application Date: 2020-02-11
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Publication No.: US11760723B2Publication Date: 2023-09-19
- Inventor: Jon Philip Lawson , Robert Christian Wild , Yiyang Shao , Jinxiao Chu , Jinchao Weng , Pavel Majer
- Applicant: DRACEN PHARMACEUTICALS, INC.
- Applicant Address: US NY New York
- Assignee: Dracen Pharmaceuticals, Inc.
- Current Assignee: Dracen Pharmaceuticals, Inc.
- Current Assignee Address: US DC Washington
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: WO TCN2019074800 2019.02.11
- International Application: PCT/US2020/017748 2020.02.11
- International Announcement: WO2020/167829A 2020.08.20
- Date entered country: 2021-08-11
- Main IPC: C07D209/20
- IPC: C07D209/20 ; C07C249/02 ; C07D207/28
Abstract:
The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical purity and >95% enantiomeric excess.
Public/Granted literature
- US20220194898A1 METHOD OF PREPARING A DON PRODRUG FROM L-PYROGLUTAMIC ACID Public/Granted day:2022-06-23
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