Invention Grant
- Patent Title: Chimeric antigen receptors targeting abnormal glycobiology
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Application No.: US16782417Application Date: 2020-02-05
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Publication No.: US11760786B2Publication Date: 2023-09-19
- Inventor: Challice L. Bonifant , Alnawaz Rehemtulla , David M. Markovitz
- Applicant: The Regents of The University Of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: CASIMIR JONES, SC
- Agent David W. Staple
- Main IPC: C07K14/725
- IPC: C07K14/725 ; C07K14/705 ; A61K35/17 ; A61P35/00 ; C12N5/0783
Abstract:
The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
Public/Granted literature
- US20200247868A1 CHIMERIC ANTIGEN RECEPTORS TARGETING ABNORMAL GLYCOBIOLOGY Public/Granted day:2020-08-06
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