Invention Grant
- Patent Title: Safe harbor loci
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Application No.: US17716816Application Date: 2022-04-08
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Publication No.: US11761004B2Publication Date: 2023-09-19
- Inventor: Xinying Zheng , Brendan Galvin , Somya Khare , Aaron Cooper , Michelle Nguyen , Anzhi Yao
- Applicant: Arsenal Biosciences, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: ARSENAL BIOSCIENCES, INC.
- Current Assignee: ARSENAL BIOSCIENCES, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Goodwin Procter LLP
- The original application number of the division: US17239484 2021.04.23
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K35/17 ; C12N5/0783 ; C12N15/11 ; C12N9/22 ; C12N15/85
Abstract:
Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.
Public/Granted literature
- US20220315928A1 SAFE HARBOR LOCI Public/Granted day:2022-10-06
Information query
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