A method of simulating defects in an analog circuit design includes, in part, defining a multitude of defect models, defining a defect scope associated with the defect models, and compiling, by a processor, the defect models, the defect scope, and a netlist associated with the analog circuit design. The method further includes, in part, scanning the netlist to identify a multitude of nodes to which a multitude of defects defined by the defect models and the defect scope are applied, injecting the multitude of defects at the identified nodes, and simulating the analog circuit design using the injected defects.