Provided is a flip chip space pixel arrangement structure, a pixel multiplexing method and system, an apparatus and a storage medium. The pixel multiplexing method includes: equidistantly dividing, in rows and columns, an LED display screen into a plurality of first element sets and a plurality of second element sets; on the basis of a pixel acquisition algorithm, sampling a single frame of original image having high resolution into seven basic images having low resolution; on the basis of a determination strategy, formulating display orders of the basic images, the single frame of original image corresponding to three display orders, and each of the display orders corresponding to one or more of the basic images; and on the basis of the display orders, sequentially displaying each of the basic images in a single frame duration, to complete sub-pixel reconstruction of the flip chip space pixel arrangement structure.