The invention is generally directed to a sterile surgical drape designed to provide a sterile barrier with a self-contained, expandable sterile pocket. The sterile surgical drape includes a pocket sized and shaped to accommodate the C-arm of an X-ray machine. The pocket spans the width of the operative site and includes an elastic band along a top edge to ensure that the pocket does not drop below the sterile field when not in use. In this way, the pocket is maintained around the C-arm and the sterile field is preserved during use. The surgical drape can optionally include an adhesive antimicrobial strip configured with an elongated length. The surgical drape can further optionally include one or more pouches sized and shaped to retain surgical instruments or tools.