Invention Grant
- Patent Title: Compositions and methods for induced brown fat differentiation
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Application No.: US16720142Application Date: 2019-12-19
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Publication No.: US11766471B2Publication Date: 2023-09-26
- Inventor: Bruce M. Spiegelman , Shingo Kajimura
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Foley Hoag LLP
- The original application number of the division: US14874697 2015.10.05
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N15/85 ; C07H21/04 ; A61K38/28 ; C07K14/47 ; A61K31/405 ; A61K31/4439 ; A61K31/573 ; C12N15/63 ; C12N5/16 ; A61K38/00
Abstract:
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both Prdm16 and C/EBPβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both Prdm16 and C/EBPβ expression and/or activity. Further provided are methods for identifying compounds that are capable of modulating both Prdm16 and C/EBPβ expression and/or activity.
Public/Granted literature
- US20200206317A1 COMPOSITIONS AND METHODS FOR INDUCED BROWN FAT DIFFERENTIATION Public/Granted day:2020-07-02
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