Invention Grant
- Patent Title: Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections
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Application No.: US17384051Application Date: 2021-07-23
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Publication No.: US11767303B2Publication Date: 2023-09-26
- Inventor: Hongmin Li , Zhong Li , Jia Zhou , Jimin Xu , Qing-Yu Zhang
- Applicant: Health Research, Inc. , Arizona Board of Regents on Behalf of the University of Arizona , Board of Regents, The University of Texas System
- Applicant Address: US NY Menands
- Assignee: HEALTH RESEARCH, INC.,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
- Current Assignee: HEALTH RESEARCH, INC.,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
- Current Assignee Address: US NY Menands; US TX Austin; US AZ Tucson
- Agency: HESLIN ROTHENBERG FARLEY & MESITI P.C.
- Main IPC: A61K31/5375
- IPC: A61K31/5375 ; C07D265/30 ; C07C233/75 ; C07D211/46 ; A61P31/14 ; C07D409/12 ; C07D213/75 ; C07D333/54

Abstract:
The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.
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