- Patent Title: Methods of synthesizing substituted pyridinone-pyridinyl compounds
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Application No.: US17533931Application Date: 2021-11-23
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Publication No.: US11767309B2Publication Date: 2023-09-26
- Inventor: Gary A. Decrescenzo , John Robert Springer
- Applicant: ACLARIS THERAPEUTICS, INC.
- Applicant Address: US PA Wayne
- Assignee: Aclaris Therapeutics, Inc.
- Current Assignee: Aclaris Therapeutics, Inc.
- Current Assignee Address: US PA Wayne
- Agency: DLA Piper LLP
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D401/14 ; C07D405/12
Abstract:
The present disclosure provides methods of synthesizing a compound of Formula (P)-I. The method proceeds through several different pathways including several novel chiral separations, a Sonogashira coupling, a zinc mediated reductive cyanation, as well as through various halide containing intermediates. Also disclosed is the multi-kilogram preparation of several novel intermediates.
Public/Granted literature
- US20230202999A9 METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS Public/Granted day:2023-06-29
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