The disclosure relates to a method for mechanochemical preparation of an iron red pigment, which comprise steps: mixing a clay mineral, a soluble iron source and an alkali source in a mill for grinding to obtain a precursor, wherein the ratio of ball to material is controlled at 20-50, the grinding speed is 300-1200 rpm, and the grinding time is 30-360 min; and calcining the precursor at 500-900° C. for 30-120 min to obtain a high-performance iron oxide red/clay mineral hybrid pigment. The iron oxide red/clay mineral hybrid pigment has a bright and beautiful color, high-temperature and acid resistance, and can satisfy requirements for high-performance iron oxide red pigments in fields of paints, inks, ceramics, anti-corrosive coatings, etc. Furthermore the method is a simple process without waste that is environmentally friendly and suitable for industrialized production, thus it is expected to replace existing processes of iron oxide red pigments.